Saul Marcus, ND - Naturopathic Doctor

247 West 35th street, 10th floor - New York, NY 10001

Phone:(646)330-0388 | Email:

Contact Office For Appointment

Adrenal Stress Index (ASI) Test Panels

Go back to previous page on functional lab tests

diagnos tech ASI test picture

TAP Panel Includes:

  • Cortisol, 4 samples throughout the day

ASI (adrenal stress index) Panel Includes:

  • Cortisol, 4 samples throughout the day
  • DHEA
  • 17-OH progesterone
  • Insulin, 2 samples
  • Salivary secretory IgA
  • Anti-gliadin IgA

Why test saliva?

Cortisol is normally 10 times higher in the morning than at night. A single sample does not demostrate that cortisol is in reference range the rest of the day. Unlike blood, saliva is a true marker of intracellular horomone activity. Saliva testing is easy to do, and does not require venipuncture.

The Saliva Cortisol Test page has more information on cortisol patterns and why saliva is used.

Who can benefit from testing cortisol?

Cortisol is the body's major stress hormone. It therefore has a profound affect on health and may be associated with the following health concerns:

  • Chronic stress and any related health problems
  • Fatiuge and low energy
  • Muscle and joint pain
  • Hypoglycemia (low blood sugar)
  • Headaches
  • Poor sleep and insomnia
  • Poor response to stress
  • Low sex drive
  • Low body temperature

An online questionnaire to see if the ASI may be right for you is available on the diagnos-tech website (note, this link will take you away from

For more general information on cortisol and adrenal fatigue go to the Adrenal Exhaustion and Chronic Fatigue page.

Cortisol tests - cost includes half hour on phone to review results

*Due to New York State law, this offer does not apply to anyone living in New York.

The markers on the ASI tests


Cortisol is a steroid hormone produced by the adrenal glands. It is the body's major stress hormone, and so has a profound effect on numerous other systems. Testing cortisol can be essential if you have symptoms of either adrenal fatigue, or high cortisol.

Cortisol along with another stress hormone, DHEA help to regulate the following systems:

Steroid hormone pathways. Pregnenolone is converted to either DHEA and androgens, or to cortisol.


DHEA is the precursor to the androgens (males hormones: testosterone and DHT). The ratio of DHEA to cortisol is helpful in interpreting test results.


Some people with adrenal fatigue will not benefit from supplements such as pregnenolone or progesterone because they are not converting 17-hydroxyprogesterone into cortisol. This marker helps to identify those people.


Cortisol works closely with insulin to regulate blood sugar. On the ASI panel, the first morning sample measures fasting insulin, and the afternoon sample is non-fasting insulin. This helps to identify problems with blood sugar regulation.

Salivary secretory IgA

Secretory IgA is a marker of immune system function along the mucosal membrane of the digestive tract. It is commonly depressed by stress.

Anti-gliadin IgA

Helps to identify people who are sensitive to wheat and other grains which have gliadin. Such sensitivities is another stress on the body and thus can affect cortisol levels.